The bisphenol F and bisphenol S and cardiovascular disease: results from NHANES 2013–2016

Abstract Background Bisphenol F (BPF) and bisphenol S (BPS) have replaced A (BPA) in the manufacturing of products containing polycarbonates epoxy resins; however, effects these substitutes on risk cardiovascular disease (CVD), including congestive heart failure, coronary disease, angina pectoris, attack, stroke, not been assessed. Objective To examine association urinary BPS BPF with CVD a U.S. representative population. Methods Cross-sectional data from 1267 participants aged 20–80 years 2013–2016 National Health Nutrition Examination Survey (NHANES) were analyzed. Survey-weighted multiple logistic regression was used to assess between BPA, BPF, CVD. The Bayesian kernel machine (BKMR) model applied mixture effect. Results total 138 patients identified. After adjusting for potential confounding factors, T3 tertile concentration increased (OR: 1.99, 95% CI 1.16–3.40). When stratified by age, we found that 50–80 age group 1.40, 1.05–1.87). positively associated 2.22 times (95% 1.04–4.74). No significant observed Although BKMR did identify mixed exposure effect BPS, increasing compound concentration. Conclusion Our results suggest may increase US population, prospective studies are needed confirm results.